A cure for one of the most prevalent and devastating diseases in the world today continues to evade us. For example, just 1% of pancreatic cancer patients and 5% of those with lung cancer are still alive 10 years after their diagnosis. The solution is to understand the molecular mechanisms that make cancer cells different to normal cells and then to develop specific drugs. With personalised, precision medicine we can analyze the mutations of each patient's cancer individually and select from the shelf drugs available for the specific mutations found in the cancer of that patient. This could suppress the cancer and convert cancer into a chronic disease. But our final main is to find therapies to wipe out cancer permanently.
One of the methods raising hopes for improved cancer treatment is CAR-T. CAR-T uses a patient’s own immune cells and re-programs the immune cells to attack cancer cells.
Certain proteins on the surface of cancer cells inhibit immune responses. These proteins keep the T cells of the patient from killing cancer cells. When these proteins are blocked, T cells are able to kill cancer cells.
Targeted cancer therapies are drugs that interfere with specific molecules involved in cancer cell growth and survival. In comparison to chemotherapy it holds the promise to attack cancer cells while doing less damage to normal cells.